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Synthetic cannabinoids are gaining popularity globally and detection is not commonly available.
Tremors were observed 30 minutes following 1 mg/kg AMB-FUBINACA in 3 of 8 mice (data not shown).
The fact that similar 4F-MDMB-BINACA and ethanol concentrations were detected in the postmortem blood samples of both victims suggests that both substances played a role in the fatal outcome.
The substitution tests occurred only if the rats had achieved 85% injection-appropriate responding on the two prior training sessions.
FOB is a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess the potentially adverse effects of test agents on the central nervous system (Boucard et al., 2010).
Response-rate data were analyzed by one-way repeated-measure analysis of variance.
All of the compounds tested in the present study depressed locomotor activity as is typical for other synthetic cannabinoids (see review by Wiley et al., 2017).
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