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All groups treated with tested synthetic cannabinoids showed decreased weight gain rate in a dose-dependent manner.
The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.
55 % of the patients required a longer admission due to symptoms such as severe tachycardia, hypertensive crise, convulsions, acute kidney insufficiency but also long-lasting, severe psychological problems .
During test sessions, both levers were active, such that ten consecutive responses on either lever led to reinforcement.
Low concentrations in blood and/or urine, extensive metabolism, and lack of efficient immunochemical urinary detection tests complicate analytical detection.
A total of 5 mice in the JWH-081 (5 mg/kg, i.p.) treated group and 6 mice in the JWH-210 (5 mg/kg, i.p.) treated group showed loss of traction, of which 4 and 5 showed tremor, respectively.
Each compound was tested in a group of at least six rats using a repeated-measure design such that each rat was tested at all doses of a given drug.
Mice were subjected to the tests 30 min and 2 h after the last injection (5th) of JWH.
Average horizontal activity counts/10 min as a function of time (10 min bins) and dose.
In locomotor activity, methamphetamine treated group showed approximately 4.2 times increase compared to the negative control treated group.
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