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Demographic and clinical features are recorded and blood and/or urine samples analysed using high-resolution accurate mass liquid chromatography-mass spectrometry.
All of the compounds tested in the present study depressed locomotor activity as is typical for other synthetic cannabinoids (see review by Wiley et al., 2017).
Substantial depressant effects were observed within the first 10 min, and maximal depression was observed between 0–30 min following administration.
From these three samples, sample 2 contained only an ester hydrolysis metabolite (m/z 350).
The reported cases and reviews of the scientific literature suggest a possible synergistic effect between SCRAs and ethanol, because their combined use clearly increases their toxicity.
Average potency of the discriminative stimulus effects of early compounds was 0.81±0.17 mg/kg (Gatch et al., 2014), whereas the potency of a recent set was 0.09±0.03 mg/kg (Gatch et al., 2018), and the potency of the current set is 0.05±0.01 mg/kg.
Low concentrations in blood and/or urine, extensive metabolism, and lack of efficient immunochemical urinary detection tests complicate analytical detection.
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