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Only a few case reports about the dangers of some synthetic cannabinoids due to neurotoxicity have been published (Cohen et al., 2012; McGuinness et al., 2012; Harris and Brown, 2013; Hermanns et al., 2013).
In addition, 2 to 5 mice treated with JWH-081 and JWH-210 fell from the rotating rod (Table 4).
FOB is a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess the potentially adverse effects of test agents on the central nervous system (Boucard et al., 2010).
The current study indicates that the test compounds produce locomotor depression similar to that of Δ9-THC, and fully substitute for the discriminative stimulus effects of Δ9-THC.
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