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The current study indicates that the test compounds produce locomotor depression similar to that of Δ9-THC, and fully substitute for the discriminative stimulus effects of Δ9-THC.
These results indicate that the simultaneous intoxication of SCRA and ethanol directly and exclusively caused the death of the two victims.
In histopathological analysis, neural cells of the animals treated with the high dose (5 mg/kg) of JWH-081 or JWH-210 showed distorted nuclei and nucleus membranes in the core shell of nucleus accumbens, suggesting neurotoxicity.
MS/MS experiments were performed in MRM (multiple reaction monitoring) mode with an isolation window of 0.4 m/z.
Male ND4 Swiss–Webster mice were obtained from Envigo (Houston, TX) at approximately 8 weeks of age and maintained in the University of North Texas Health Science Center (UNTHSC) animal facility for two weeks prior to testing.
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